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The NFM Blog

Pain Relief from Nature: Finding the Best Mushroom for Pain Management


Mushrooms are like the definition of versatile. They are of many kinds and often boast a lot of benefits. When we think about mushrooms, we often think about:

1. Button mushrooms

2. Shitake mushrooms 

3. Oyster mushrooms or even

4. Portobello mushrooms

Each of them has a distinct and great taste profile and will definitely elevate your dish. But today we are focusing on the world of medicinal mushrooms. In this blog, we will explore the perspectives on using mushrooms for pain relief, what the best mushroom for pain relief might be, the history of mushroom usage, the modern perspectives on mushrooms, and the ever-growing interest in natural pain management alternatives for chronic conditions. 

Overview of Medicinal Mushrooms for Pain Relief

Medicinal Mushrooms have been used for centuries in traditional medicine to help with a variety of ailments, mostly like pain and inflammation. Research has shown that the therapeutic compounds found in mushrooms such as beta-glucans, D-fraction, and anti-inflammatory agents, making them essential for managing pain.

Historical and modern research perspectives

As mentioned before mushrooms have been used for centuries to treat ailments. This has been the case among various cultures around the world like the Chinese, Egyptians, Greeks, and Romans.  These have been well documented. 

Despite the historical evidence, mushrooms have always been a talking point. Only recently modern research has concluded that mushrooms have powerful properties that help in ailments. Mushrooms are essentially nature’s miniature pharmaceutical factories, having a vast array of novel constituents like bioactive compounds. Studies show that beta-glucans, polysaccharides, triterpenes, and other bioactive molecules in mushrooms which exhibits anti-inflammatory, analgesic, immunomodulatory, and neuroprotective properties.

There have been many clinical trials and studies done to explore the efficacy of different species of mushrooms to identify what the best mushroom for pain relief might be. The evidence positively supports the therapeutic properties of mushrooms and this has further fueled interest in terms of integrating mushrooms into modern medicine, alternative remedies, and supplements. 

Understanding Mushroom Medicinal Benefits

Finding the Best Mushroom for Pain Management

Research has uncovered why medicinal mushrooms were used in the past times, here are some of the key factors:

These are complex sugars found inside of mushrooms. They may stimulate the immune system and have anti-inflammatory properties.

D-fraction is a unique compound that is extracted from certain types of mushrooms, this compound aids in improving the immune system. 

Anti-inflammatory and pain relief compounds:
This is a common trait in many medicinal mushrooms. The bioactive compounds demonstrate anti-inflammatory properties and provide analgesic effects. 

Now that we are familiar with medicinal mushrooms, let’s take a look at —

10 Best Mushrooms for Pain Relief

Lion’s Mane also known as Hericium Erinaceus
This mushroom promotes nerve health and regeneration of nerves and is beneficial for nerve pain. 

Cordyceps scientifically known as Cordyceps Sinensis
Is renowned for its energy-boosting properties, known to improve your stamina and endurance, and its anti-aging properties. 

Reishi (Ganoderma Lucidum)

Reishi mushrooms are known for their immune system modulation and anti-inflammatory properties.

Chaga (Inonotus Obliquus)

This unique mushroom shows the potential to support immune function and reduce inflammation.

King Trumpet (Pleurotus Eryngii)

King Trumpet mushrooms might play a role in blood sugar control and oxidative stress management, which can contribute to chronic pain.

Turkey Tail (Trametes Versicolor)

Famed for its immune system support, Turkey Tail mushrooms may also offer pain reduction benefits.

Shiitake (Lentinula Edodes)

A popular culinary mushroom, Shiitake exhibits potential anti-inflammatory properties that might be relevant for pain management.

Maitake (Grifola Frondosa)

Maitake mushrooms hold promise for immune system support and inflammation reduction, potentially aiding in pain management.

Psilocybin Mushrooms (Psilocybe Cubensis)

Studies suggest psilocybin, a psychoactive compound in these mushrooms, may help regulate pain perception. However, legal and safety considerations require caution.

Agaricus blazei (Agaricus Subrufescens)

This mushroom demonstrates potential for immune-boosting and anti-inflammatory effects, which may contribute to pain relief.

Note: The list is not exhaustive, and further research and studies are needed to solidify these claims of pain-relieving and other properties of each mushroom mentioned above. 

How to Use Mushrooms to Benefit from Their Pain-Relieving Properties

There are two main ways to incorporate medicinal mushrooms into your routine:

Fresh Mushrooms

Cooking Mushrooms and adding them to your diet allows you to enjoy their flavor and their potential health benefits at the same time, especially if you enjoy Mushrooms on the regular. If you are new to the world of mushrooms maybe this guide about mushroom consumption might help. 

Mushroom Supplements
A brilliant way of adding the benefits of mushrooms into your diet without any hassle, especially if you are not a huge fan of eating mushrooms. The mushroom supplement is ever-growing and comes in a variety of forms. We feel powdered form or liquid extracts are the best way to go it might come across as biased but we believe in our vision. 

Note: Whether it's Fresh Mushrooms or Mushroom Supplements always consult with a healthcare professional before starting to add them to your diet. 

Here are some Do’s and Don’ts you need to keep in mind when exploring medicinal mushrooms for pain relief. 

As mentioned above, be sure to visit a healthcare professional before introducing mushrooms to your routine.  Discuss specific pain conditions and any medications for a safer approach. 

Follow the correct dosage guidelines.


Avoid Unverified Sources:
When purchasing mushrooms or supplements, ensure they are from a reputed vendor. The sourcing practices should be transparent and they should be third-party tested to ensure the best quality of ingredients. 

Psilocybin Mushrooms:

While Psilocybin research is definitely promising. In many parts of the world, these mushrooms are deemed to be illegal due to their hallucinogenic effects. So proceed with caution if dealing with these kinds of mushrooms and ensure you read what the ingredients are. 

Conclusion: Finally what is the best mushroom for pain relief?

The world of medicinal mushrooms is still a vast area that is unexplored and plenty of research is still yet to be done, it also offers exciting alternatives for pain management. While each of the mushrooms mentioned above are good in their own right, our picks are definitely Lion’s Mane, Cordyceps, and Reishi which show the best results in terms of the volume of their anti-inflammatory and analgesic properties.

Also, every individual is different, there is no one-size-fits-all approach when it comes to picking a mushroom for pain relief. It is definitely found out through trial and error.

Our 3 picks of Mushrooms can be found in our signature blends of  LIFT, LIFE MIND, CALM, and SLEEP.

So come explore the world of natural wellness options through Mushrooms with Non-Fungible Mushrooms

Disclaimer: This blog here is intended for informational purposes only. It should not be confused with medical advice. As mentioned throughout the blog always consult with a qualified healthcare professional before making any dietary or lifestyle changes.